Flow Chemistry
Providing Safe, Efficient, and Economical Drug Manufacturing
Porton has heavily invested resources in establishing and developing R&D and manufacturing capabilities for continuous reactions. Our goal is to enhance safety and efficiency in the drug manufacturing process, expand the variety of reactions, and provide more options for designing API synthesis routes.
R&D
Porton's dedicated continuous reaction laboratory at the Minhang R&D Center in Shanghai can undertake the development work to convert various types of reactions from batch to continuous mode, as well as screen and optimize continuous reaction process parameters. It is also capable of kilogram-scale production. The R&D laboratory currently houses various types of continuous reactors, including microchannel reactors and continuous photochemistry reactor and continuous hydrogenation reactor, coil reactors made of different materials, small continuous stirred tank reactors (CSTRs), and various independent operational units such as different types of pumps, recirculating temperature control baths, and backpressure valves.
Production
Chongqing Changshou Manufacturing Site can undertake the technology transfer, pilot verification, and commercial-scale production of continuous reaction processes. We have already completed several R&D and production projects involving continuous reactions, such as nitration, ozonolysis, azidation, butyllithium reactions, and Grignard reagent reactions. In addition to reactions, Porton has also successfully established continuous post-processing capabilities for continuous extraction, quenching, and liquid-liquid separation.
Continuously enriching our R&D and production equipment inventory for continuous production (to meet project flexibility and versatility needs): tubular reactors, continuous stirred-tank reactors (CSTRs), Flow rate control modules by PLC, temperature control units (TCUs), ovens, ozone generators, and more.
Handling highly hazardous, highly polluting, and fast reaction rate processes.
Reactions requiring precise control of reaction time and timely quenching.
Committed to enhancing the inherent safety of pharmaceutical manufacturing processes.
Using multiple independent modular units to assemble production lines, meeting project needs for flexibility and versatility.
Regular and commercial projects utilize fixed integrated units.
Making synthetic route design more flexible and selective.
