Co-processing Series: 3. Adsorption -Case Studies & Whitepapers-End-to-end CDMO | Porton Pharma Solutions

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Case Studies & Whitepapers2024-10-28

Co-processing Series: 3. Adsorption

Xiaoyi Ding, a research scientist at Porton J-STAR, introduces adsorption as an important co-processing technique. This method involves the absorption of a dissolved drug into the pores of a carrier material, known as an adsorbent, with the drug remaining embedded in the porous media post-drying. A significant advantage of this technique is its ability to render the drug substance amorphous within the confined porous space without the need of a stabilizing polymer, enhancing the solubility and b
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Case Studies & Whitepapers2025-02-10

Efficacy and Safety - Guidelines for Clinical In-use Stability Studies of ADCs

Antibody-drug conjugates (ADCs) consist of three parts: antibody, linker, and payload. This special combination enables ADCs to selectively target tumor cells and release cytotoxic drugs, but they face many stability challenges during manufacture, storage, and clinical use. In this paper, the drug product development team at Porton (hereinafter referred to as "we") discusses the necessary clinical in-use stability studies for ADCs.

Case Studies & Whitepapers2025-01-06

Molecular Modeling and Data Science for De-risking and Cost- saving of Pharmaceutical Development

Molecular Modeling and Data Science for De-risking and Cost- saving of Pharmaceutical Development
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