Preformulation Strategy- Inception to Completion

Drug discovery is an exceedingly complex process. Discovering a new chemical entity is in itself a huge accomplishment, which is often possible only after almost two decades of hard experimental work as well as advanced simulation efforts. Therefore, the next stage of the process, determination of toxicity becomes even more crucial as most new chemical entities (NCE) are disqualified if the NCE shows a potential toxic effect, despite any possible therapeutic effect.

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Facilitating PROTAC Drugs Development with Innovative Processes

The PROTAC technology, through an innovative mechanism of "degradation rather than inhibition," provides a new pathway for targeting traditionally undruggable proteins and addressing resistance issues.

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Continuous Improvement of Project Life Cycle Management, Benefiting Customers by Reducing Total Cost

Continuous Improvement of Project Life Cycle Management, Benefiting Customers by Reducing Total Cost

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Molecular Modeling and Data Science for De-risking and Cost- saving of Pharmaceutical Development

Molecular Modeling and Data Science for De-risking and Cost- saving of Pharmaceutical Development

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Co-processing: Co-Precipitation Technology (CPT) for the Enhancement of Flowability and Bulk Density

Formulating compressed tablets is one of the most widely used oral solid form dosages. However, a vital first step is choosing a suitable manufacturing approach and the right excipients to support the desired therapeutic effect.

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ENT-03 GRC Poster

ENT-03 was predicted to be the mammalian equivalent of trodusquemine, based on knowledge of the bile acids produced in mammals, such as 7-HOCA. The individual C-25 isomers of ENT-03 were prepared and both detected in mouse brain. Trodusquemine and ENT-03 have both demonstrated dramatic effects in obesity and insulin resistance. (25S)-ENT-03 was selected for development for the treatment of diabetes and obesity.

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